Retinoic Acid Receptor, α-Isotype Antibody

Applications

Reactivity

Human
Mouse
Rat

Predicted Reactivity

Dog
Bovine
Guinea Pig

Overview
Catalog #	bsm-70244M
Product Name	Retinoic Acid Receptor, α-Isotype Antibody
Applications	WB
Specificity	Specific for endogenous levels of the ~48 kDa RAR-α isotype.
Reactivity	Human, Mouse, Rat
Predicted Reactivity	Dog, Bovine, Guinea Pig
Specifications
Conjugation	Unconjugated
Host	Mouse
Source	Synthetic peptide corresponding to amino acid residues from the N-terminal region of human retinoic acie receptor, α-isotype, conjugated to keyhole limpet hemocyanin (KLH).
Clonality	Monoclonal
Clone #	763
Isotype	IgG1
Concentration	Lot Dependent
Purification	Purified by Protein G.
Storage Buffer	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Gene ID	5914
Swiss Prot	P10276
Synonyms	NR1B1 antibody, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody, Nuclear receptor subfamily 1 group B member 1 antibody, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody, RAR alpha antibody, RAR antibody, RAR-alpha antibody, rara antibody, RARA_HUMAN antibody, RARalpha antibody, RARalpha1 antibody, Retinoic acid nuclear receptor alpha variant 1 antibody, Retinoic acid nuclear receptor alpha variant 2 antibody, Retinoic acid receptor alpha antibody, Retinoic acid receptor alpha polypeptide antibody
Background	Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
Application Dilution
WB	1:300-5000