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Calbindin Antibody

Applications

  • WB
  • IHC

Reactivity

  • Human
  • Mouse
  • Rat
  • Bovine
Overview
Catalog # bsm-70028M
Product Name Calbindin Antibody
Applications WB, IHC
Specificity Specific for endogenous levels of the ~28 kDa calbindin protein.
Reactivity Human, Mouse, Rat, Bovine
Specifications
Conjugation Unconjugated
Host Mouse
Source Recombinant full length human calbindin purified from E. coli.
Clonality Monoclonal
Clone # 5A9
Isotype IgG2a
Concentration Lot Dependent
Purification Purified by Protein G.
Storage Buffer PBS + 50% glycerol and 5 mM NaN3
Storage Condition Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Gene ID 793
Swiss Prot P05937
Synonyms avian-type antibody, CAB27 antibody, CALB 1 antibody, CALB antibody, CALB1 antibody, CALB1_HUMAN antibody, Calbindin 1 28kDa antibody, Calbindin antibody, Calbindin D28 antibody, D 28K antibody, D-28K antibody, D28K antibody, OTTHUMP00000166027 antibody, OTTHUMP00000225441 antibody, RTVL H protein antibody, Vitamin D dependent calcium binding protein antibody, Vitamin D dependent calcium binding protein avian type antibody, Vitamin D-dependent calcium-binding protein antibody
Background Calbindin (aka. calbindin D28k) is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is predominantly expressed in certain types of neurons, particularly in dendrites and perikarya of the cerebellum and is thought to buffer entry of calcium upon stimulation of glutamate receptors (Andressen et al., 1993). Calbindin has recently been shown to play a critical role in mitochondrial dysfunction and loss of synaptic proteins in vivo in an Alzheimer’s disease mouse model (Kook et al., 2014).
Application Dilution
WB 1:300-5000
IHC