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Alpha Synuclein Antibody

Applications

  • WB
  • IHC
  • ICC

Reactivity

  • Human
  • Mouse
  • Rat
  • Bovine
  • Pig
Overview
Catalog # bsm-70013M
Product Name Alpha Synuclein Antibody
Applications WB, IHC, ICC
Specificity Specific for the endogenous levels of the ~15 kDa alpha synuclein protein.
Reactivity Human, Mouse, Rat, Bovine, Pig
Specifications
Conjugation Unconjugated
Host Mouse
Source Full length human alpha synuclein expressed in E. Coli.
Clonality Monoclonal
Clone # 2A7
Isotype IgG1
Concentration Lot Dependent
Purification Purified by Protein G.
Storage Buffer PBS + 50% glycerol and 5 mm NaN3
Storage Condition Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Gene ID 6622
Swiss Prot P37840
Synonyms Alpha synuclein antibody, Alpha-synuclein antibody, Alpha-synuclein, isoform NACP140 antibody, alphaSYN antibody, MGC105443 antibody, MGC110988 antibody, MGC127560 antibody, MGC64356 antibody, NACP antibody, Non A beta component of AD amyloid antibody, Non A4 component of amyloid antibody, Non A4 component of amyloid precursor antibody, Non-A beta component of AD amyloid antibody, Non-A-beta component of alzheimers disease amyloid , precursor of antibody, Non-A4 component of amyloid precursor antibody, Non-A4 component of amyloid, precursor of antibody, OTTHUMP00000218549 antibody, OTTHUMP00000218551 antibody, OTTHUMP00000218552 antibody, OTTHUMP00000218553 antibody, OTTHUMP00000218554 antibody, PARK 1 antibody, PARK 4 antibody, PARK1 antibody, PARK4 antibody, Parkinson disease (autosomal dominant Lewy body) 4 antibody, Parkinson disease familial 1 antibody, SNCA antibody, Snca synuclein alpha (non A4 component of amyloid precursor) antibody, SYN antibody, Synuclein alpha antibody, Synuclein alpha 140 antibody, Synuclein alpha (non A4 component of amyloid precursor) antibody, SYUA_HUMAN antibody
Background Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (ChartierHarlin MC et al., 2004 and Singleton, AB et al., 2005). Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).
Application Dilution
WB 1:300-5000
IHC
ICC 1:100-500