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Alpha II Spectrin Antibody

Applications

  • WB
  • IHC
  • ICC

Reactivity

  • Human
  • Mouse
  • Rat
  • Bovine
Overview
Catalog # bsm-70005M
Product Name Alpha II Spectrin Antibody
Applications WB, IHC, ICC
Specificity Specific for endogenous levels of the ~240 kDa alpha II spectrin protein.
Reactivity Human, Mouse, Rat, Bovine
Specifications
Conjugation Unconjugated
Host Mouse
Source Recombinant contstruct containing the 7th, 8th, 9th repeats of human alpha II spectrin.
Clonality Monoclonal
Clone # 3D7
Isotype IgG1
Concentration Lot Dependent
Purification Purified by Protein G.
Storage Buffer PBS + 50% glycerol and 5 mm NaN3
Storage Condition Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Gene ID 6709
Swiss Prot Q13813
Synonyms (ALPHA)II-SPECTRIN antibody, Alpha-II spectrin antibody, brain antibody, EIEE5 antibody, 7738 antibody, FLJ44613 antibody, Fodrin antibody, Fodrin alpha chain antibody, Fodrin, alpha antibody, NEAS antibody, Non erythrocytic spectrin alpha antibody, non-erythroid alpha chain antibody, SPECA antibody, Spectrin alpha chain antibody, Spectrin alpha chain brain antibody, Spectrin alpha non erythrocytic 1 antibody, Spectrin antibody, Spectrin non erythroid alpha chain antibody, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) antibody, Spectrin, nonerythroid, alpha subunit antibody, Spna2 antibody, SPTA 2 antibody, SPTA2 antibody, SPTA2_HUMAN antibody, SPTAN 1 antibody, SPTAN1 antibody
Background The spectrin family of cytoskeletal proteins is comprised of 2 alpha genes (α1 and α2) and five beta genes (β1-β5). Spectrins have been shown to function as scaffolding proteins in mechanical support of the plasma membrane as well as bind other membrane proteins and lipids (Bennett and Baines 2001). Defects in spectrin genes have been linked to some forms of hereditary spherocytosis, a type of auto-hemolytic anemia which is characterized by spherical red blood cells that are more prone to lysis (Eber and Lux 2004).
Application Dilution
WB 1:300-5000
IHC
ICC 1:100-500