PAG1 Monoclonal Antibody

Overview
Catalog #	bsm-62406r-100ul
Product Name	PAG1 Monoclonal Antibody
Applications	WB, FCM, IHC-P, IHC-F, IP, IF
Reactivity	Human, Mouse, Rat
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human PAG1
Clonality	Monoclonal
Clone #	Recombinant
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage Condition	Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	55824
Swiss Prot	Q9NWQ8
Subcellular location	Cell membrane
Synonyms	CBP; Csk binding protein; PAG; PAG1.
Background	Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Application Dilution
WB	:1:1000-1:2000
FCM	FCM:1:20-1:100
IHC-P	IHC-P:1:100-1:200
IHC-F	IHC-F:1:100-1:200
IP	IP:1:20-1:50
IF	IF:1:100-1:200