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CD34 monoclonal Antibody

Applications

  • FCM
  • IHC-P

Reactivity

  • Human
  • Mouse
  • Rat
  • Dog
Overview
Catalog # bsm-54470R
Product Name CD34 monoclonal Antibody
Applications FCM, IHC-P
Reactivity Human, Mouse, Rat, Dog
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant human CD34
Clonality Monoclonal
Clone # 7A1
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein G.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 947
Swiss Prot P28906
Subcellular location Cell membrane
Synonyms CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN.
Background The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
Application Dilution
FCM 1:20-100
IHC-P 1:200-400