Overview |
bsm-54439R |
NXF1 (1G8) Monoclonal Antibody |
WB, IF(ICC), IP |
Human |
Specifications |
Unconjugated |
Rabbit |
Recombinant protein within c-terminal human NXF1. |
Monoclonal |
1G8 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at -20°C for 12 months. |
Target |
10482 |
Q9UBU9 |
Cytoplasm, Nucleus |
Nuclear RNA export factor 1; Tip-associated protein; Tip-associating protein; mRNA export factor TAP; NXF1; MEX67; TAP |
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. |
Application Dilution |
WB |
1:300-5000 |
IF(ICC) |
1:50-200 |
IP |
1-2ug |