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CD46 (4C3) Monoclonal Antibody

Applications

  • WB
  • IHC-P
  • IF(IHC-P)
  • IF(ICC)

Reactivity

  • Human
  • Rat
Overview
Catalog # bsm-54335R
Product Name CD46 (4C3) Monoclonal Antibody
Applications WB, IHC-P, IF(IHC-P), IF(ICC)
Reactivity Human, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source Synthetic peptide within human CD46 aa 50-100
Clonality Monoclonal
Clone # 4C3
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 4179
Swiss Prot P15529
Synonyms Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; CD46; MCP; MIC10; AHUS2;
Background Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Application Dilution
WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200