NR2C2 Monoclonal Antibody

$Lane 1: PC-3 cell lysates; Lane 2: Jurkat cell lysates; Lane 3: Hela cell lysates; Lane 4: Molt-4 cell lysates; Lane 5: F9 cell lysates; Lane 6: NIH\/3T3 cell lysates; Lane 7: PC-12 cell lysates; Lane 8: CHO cell lysates probed with NR2C2 Monoclonal Antibody, Unconjugated (bsm-51759M) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.$

Lane 1: PC-3 cell lysates; Lane 2: Jurkat cell lysates; Lane 3: Hela cell lysates; Lane 4: Molt-4 cell lysates; Lane 5: F9 cell lysates; Lane 6: NIH\/3T3 cell lysates; Lane 7: PC-12 cell lysates; Lane 8: CHO cell lysates probed with NR2C2 Monoclonal Antibody, Unconjugated (bsm-51759M) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.

Applications

Predicted Reactivity

Human

Overview
Catalog #	bsm-51759M
Product Name	NR2C2 Monoclonal Antibody
Applications	WB
Predicted Reactivity	Human
Specifications
Conjugation	Unconjugated
Host	Mouse
Source	KLH conjugated synthetic peptide derived from human NR2C2
Clonality	Monoclonal
Clone #	G9R1
Concentration	0.5ug/ul
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	7182
Swiss Prot	P49116
Subcellular location	Nucleus
Synonyms	NR2C2_HUMAN; Nuclear hormone receptor TR4; Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; TAK1; Testicular nuclear receptor 4; Testicular receptor 4; TR2R1; TR4; TR4 nuclear hormone receptor.
Background	Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Application Dilution
WB	=1:500-2000Ôºå