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JUP (6C1) Monoclonal Antibody

Applications

  • WB

Reactivity

  • Human
Overview
Catalog # bsm-51188M
Product Name JUP (6C1) Monoclonal Antibody
Applications WB
Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Source This JUP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 636-663 amino acids from human JUP .
Clonality Monoclonal
Clone # 6C1
Isotype IgG3
Concentration 0.5ug/ul
Purification Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 3728
Swiss Prot P14923
Synonyms DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12; Junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3; JUP
Background Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Application Dilution
WB 1:300-5000