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BLNK (5C1) Monoclonal Antibody

Applications

  • WB

Reactivity

  • Human
Overview
Catalog # bsm-51158M
Product Name BLNK (5C1) Monoclonal Antibody
Applications WB
Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Source This BLNK antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from human BLNK.
Clonality Monoclonal
Clone # 5C1
Isotype IgM
Concentration 0.5ug/ul
Purification Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 29760
Swiss Prot Q8WV28
Synonyms bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; BLNK
Background Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Application Dilution
WB 1:300-5000