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Bcl-2 monoclonal Antibody, PE-Cy5 Conjugated

Applications

  • WB

Reactivity

  • Human
  • Mouse
  • Rat
  • Bovine
  • Dog
  • Pig
  • Sheep
  • Rabbit
  • Horse
  • Guinea Pig
Overview
Catalog # bsm-33413M-PE-Cy5
Product Name Bcl-2 monoclonal Antibody, PE-Cy5 Conjugated
Applications WB
Reactivity Human, Mouse, Rat, Bovine, Dog, Pig, Sheep, Rabbit, Horse, Guinea Pig
Specifications
Conjugation PE-Cy5
Host Mouse
Source KLH conjugated synthetic peptide derived from human Bcl-2
Immunogen Range 51-150/239
Clonality Monoclonal
Clone # 4H1
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein G.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 596
Swiss Prot P10415
Subcellular location Cytoplasm, Nucleus, Cell membrane
Synonyms Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN.
Background The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).
Application Dilution
WB 1:300-5000