Plasminogen activator A Polyclonal Antibody

Applications

IHC-P
IF(IHC-P)

Reactivity

Bacteria

Overview
Catalog #	bs-9846R
Product Name	Plasminogen activator A Polyclonal Antibody
Applications	IHC-P, IF(IHC-P)
Reactivity	Bacteria
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from Streptococcus uberis PauA protein
Immunogen Range	255-350/2876
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	24161944
Swiss Prot	B9DW72
Subcellular location	Extracellular, Secreted
Synonyms	PauA; Plasminogen activator A; SUB1785; Streptokinase; Streptococcus uberis
Background	Plasminogen activator A (PauA) is a Streptococcus uberis protein that functions similarly to proteins within the Staphylokinase/Streptokinase family. Streptococcus uberis is a common cause of infection and inflammatory disease in the bovine udder. Inflammation of breast tissue (mastitis) has been recognized as a serious threat to the welfare of the dairy cow and has a severe economic impact on the dairy industry. S. uberis has been shown to specifically activate bovine and ovine plasminogen and this is mediated by the extracellular protein, plasminogen activator uberis (PauA), which has a molecular mass of around 30 kDa. It has been postulated that activation of plasminogen by PauA may facilitate early bacterial colonization of the lactating gland by promoting the release of nutrients which are likely to be restricted in milk. (https://www.ncbi.nlm.nih.gov/pubmed/10483719).
Application Dilution
IHC-P	1:200-400
IF(IHC-P)	1:50-200