RNF62 Polyclonal Antibody, APC-Cy5 Conjugated
Applications
Reactivity
Overview | |
Catalog # | bs-9379R-APC-Cy5 |
Product Name | RNF62 Polyclonal Antibody, APC-Cy5 Conjugated |
Applications | WB, IF(IHC-P) |
Reactivity | Human, Mouse, Rat |
Specifications | |
Conjugation | APC-Cy5 |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human MKRN2/RNF62 |
Immunogen Range | 261-360/416 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 23609 |
Synonyms | HSPC070_ Makorin 2; Makorin ring finger protein 2; Makorin2; Makorin-2 MKRN 2; RING finger protein 62; RNF 62; RNF62; MKRN2_HUMAN; Probable E3 ubiquitin-protein ligase makorin-2; RING finger protein 62. |
Background | The Makorins are a family of putative ribonucleoproteins containing two to four C3H zinc fingers that may confer RNA-binding. In addition, they contain a C3HC4 RING zinc finger that allows them to function as E3 ubiquitin ligases. Makorin-2, also known as RNF62, HSPC070 or MKRN2, is a widely expressed, evolutionarily conserved protein with four C3H-type zinc fingers (three at the N-terminus and one at the C-terminus), one RING-type zinc finger and a cysteine and histidine motif similar to that found in Makorin-1. In Xenopus, Makorin-2 functions, via PI 3-kinase/Akt signaling, as a negative regulator of neurogenesis. In humans, Makorin-2 is overexpressed in various cancer cell lines, suggesting a possible role of Makorin-2 in tumor progression. In addition, Makorin-2 is co-expressed with Raf-1 in the same tissues and cell lines. |
Application Dilution | |
WB | 1:300-5000 |
IF(IHC-P) | 1:50-200 |