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10074-G5

Overview
Catalog # bs-83447c-25mg
Product Name 10074-G5
Specifications
Storage Buffer Orange solid
Storage Condition -20°C
Target
Product Information Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity.1 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 mM.1 It was cytotoxic in C-Myc-overexpressing cell lines (IC50s = 13 to 15 mM) but was not active in vivo due to rapid metabolism.2 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes.3,4 Binds to and sequesters the intrinsically disordered amyloid-β (Aβ) in its monomeric soluble state and rescues a C. elegans model of Aβ-associated toxicity.5
Description CAS Number: 413611-93-5

Chemical Name: c-Myc inhibitor

Molecular Weight: 332.32

Formula: C18H12N4O3

Solubility: DMSO (40 mg/ml)

Physical Properties: Orange solid

Purity: 98% by TLC NMR (Conforms)