GW788388
| Overview | |
| Catalog # | bs-83131c-5-mg |
| Product Name | GW788388 |
| Specifications | |
| Storage Buffer | Pale pink solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Potent inhibitor of TGF-β receptor kinases ALK4, ALK5 (IC50=18 nM), ALK7, and TGFβRII, but not BMP type II receptor kinase.1,2 Blocks TGF-β-mediated signaling, including collagen type I and VEGF, in turn reducing fibrosis and angiogenesis in various mouse models.3,4 GW788388 attenuates TGF-β-induced epithelial to mesenchymal transition (EMT) in human peritoneal mesothelial cells.5 |
| Description | CAS Number: 452342-67-5 Chemical Name: 4-(4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide Molecular weight: 425.49 Formula: C25H23N5O2 Solubility: DMSO (18 mg/ml with warming) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms) |
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