PI-103
| Overview | |
| Catalog # | bs-83119c-5-mg |
| Product Name | PI-103 |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48, 20, 83 and 2 nM for p110α, p110ß, p110γ, p110δ, mTORC1, mTORC2 and DNA-PK respectively.1,2 Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation.3 Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines.4 Induces autophagy in drug-resistant glioma.5 Protects against a-synuclein-induced toxicity in human neurons by induction of macroautophagy.6 |
| Description | CAS Number: 371935-74-9 Chemical Name: 3-[4-(4-morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol Molecular weight: 348.36 Formula: C19H16N4O3 Solubility: DMSO (40 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms) |
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