PI-103

Overview
Catalog #	bs-83119c-5-mg
Product Name	PI-103
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48, 20, 83 and 2 nM for p110α, p110ß, p110γ, p110δ, mTORC1, mTORC2 and DNA-PK respectively.1,2 Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation.3 Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines.4 Induces autophagy in drug-resistant glioma.5 Protects against a-synuclein-induced toxicity in human neurons by induction of macroautophagy.6
Description	CAS Number: 371935-74-9 Chemical Name: 3-[4-(4-morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol Molecular weight: 348.36 Formula: C19H16N4O3 Solubility: DMSO (40 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)