Biotin-isoxazole

Overview
Catalog #	bs-83117c-1-mg
Product Name	Biotin-isoxazole
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Exposure of cell or tissue lysates to biotin-isoxazole precipitates hundreds of RNA-binding proteins with significant overlap to the constituents of RNA granules.1,2 In one study roughly 580 nuclear proteins were identified as being precipitated by B-Isox including TAF15, RNA polymerase II (largest subunit), numerous subunits of the mediator complex as well as a variety of enzymes involved in epigenetic modification of histones.3 SR domains were found to be the determinant that facilitates B-Isox precipitation.4 Also allows for the fractionation / isolation of SG-associated proteins and RNA precipitates.5
Description	CAS Number: 1377605-22-5 Chemical Name: 6-(5-(Thiophen-2-yl)isoxazole-3-carboxamido)hexyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate Molecular weight: 520.66 Formula: C24H32N4O5S2 Solubility: DMSO (30 mg/ml) Physical Properties: beige solid Purity: 98% by TLC nMR (Conforms)