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Fludarabine

Overview
Catalog # bs-83082c-10-mg
Product Name Fludarabine
Specifications
Storage Buffer Colorless to pale yellow oil
Storage Condition -20°C
Target
Product Information A synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.1 In cells fludarabine accumulates as its 5’-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate.2 F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase.2 A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation.3 Immunosuppressive effects are mediated via inhibition of TNF-stimulated production of IL-2 and IFN- through inactivation of NFB.4 Antagonist at adenosine A1 receptors.5
Description CAS Number: 21679-14-1

Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine;

Molecular weight: 285.23

Formula: C10H12FN5O4

Solubility: DMSO (30 mg/ml)

Physical Properties: White solid

Purity: 98% by HPLC NMR (Conforms)