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GKT-137831

Overview
Catalog # bs-83080c-5-mg
Product Name GKT-137831
Specifications
Storage Buffer White solid
Storage Condition -20°C
Target
Product Information NADPH oxidase, NOX1/4 inhibitor (Ki = 100-150 nM).1 Inhibits erastin-stimulated ROS production.2 Potentiates immunotherapy by overcoming cancer-associated fibroblast- mediated CD8+ T-cell exclusion.3 Reduces ROS production in LPS-stimulated platelets in a mouse model.4 Reduces subarachnoid hemorrhage-induced neuronal death.5 Potent inhibitor of experimental liver fibrosis in mouse models.6
Description CAS Number: 1218942-37-0

Chemical Name: 2-(2-Chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione

Molecular weight: 394.85

Formula: C21H19ClN4O2

Solubility: DMSO (65 mg/ml)

Physical Properties: Pale-yellow solid

Purity: 98% by TLC NMR (Conforms)