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SX-682

Overview
Catalog # bs-83062c-5-mg
Product Name SX-682
Specifications
Storage Buffer Off-white solid
Storage Condition -20°C
Target
Product Information SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM)1. It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer.2 It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy.3 SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.4,5
Description CAS Number: 1648843-04-2

Chemical Name: [2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid

Molecular weight: 467.20

Formula: C19H14BF4N3O4S

Solubility: DMSO (>25 mg/ml)

Physical Properties: Off-white solid

Purity: 98% by HPLC NMR (Conforms)