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Alectinib

Overview
Catalog # bs-83023c-5-mg
Product Name Alectinib
Specifications
Storage Buffer Off-white solid
Storage Condition -20°C
Target
Product Information Alectinib is a potent (IC50 = 1.9 nM) and highly selective ALK inhibitor.1 It blocked phosphorylation of both native ALK and the L1196M, C1156Y, and F1174L mutants. Alectinib has also been shown to inhibit RET kinase (IC50 = 4.8 nM), the RET gatekeeper mutations V804L and V804M, and inhibited the growth of RET fusion positive cells.2 Alectinib is clinically useful in the treatment of ALK-positive Non-Small Cell Lung Cancer. It effectively suppressed cell proliferation and induced apoptosis in a mouse neuroblastoma xenograft.3
Description CAS Number: 1256580-46-7

Chemical Name: 9-Ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

Molecular weight: 482.62

Formula: C30H34N4O2

Solubility: DMSO (5 mg/ml)

Physical Properties: White solid

Purity: 99% by HPLC NMr (Conforms)