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Crenolanib

Overview
Catalog # bs-83017c-5-mg
Product Name Crenolanib
Specifications
Storage Buffer Pale yellow solid
Storage Condition -20°C
Target
Product Information Crenolanib is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; ß = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRα mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4
Description CAS Number: 670220-88-9

Chemical Name: 1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazole-1-yl]quinoline-8-yl]piperidin-4-amine

Molecular weight: 443.55

Formula: C26H29N5O2

Solubility: DMSO (15 mg/ml) Ethanol (10 mg/ml)

Physical Properties: White solid

Purity: 97% by HPLC NMR (Conforms)