CB-103
| Overview | |
| Catalog # | bs-83004c-20-mg |
| Product Name | CB-103 |
| Specifications | |
| Storage Buffer | Pale yellow solid |
| Storage Condition | RT |
| Target | |
| Product Information | Orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 µM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines. CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors. |
| Description | CAS Number: 218457-67-1 Chemical Name: 5-Amino-2-(4-tert-butylphenoxy)pyridine Molecular weight: 242.32 Formula: C15H18N2O Solubility: DMSO (>30 mg/ml) Physical Properties: Off-white to pale orange solid Purity: 98% by HPLC, NMR (Conforms) |
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