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GSK2334470

Overview
Catalog # bs-83002c-5-mg
Product Name GSK2334470
Specifications
Storage Buffer Off-white solid
Storage Condition -20°C
Target
Product Information Potent (IC50 = 10 nM) and selective inhibitor of 3-Phosphoinositide-dependent kinase 1 (PDK1), which phosphorylates and activates a group of protein kinases in the AGC/PKG/PKC family.1 It is more effective at inhibiting PDK1 substrates that are activated in the cytosol rather than at the plasma membrane.1 GSK2334470 delayed melanogenesis and metastasis in Braf(V600E)::Pten(-/-) mice.2 It also displays antitumor activity against multiple myeloma synergistically with mTORC1/2 inhibitor PP2423 and proteasome inhibitor MG-1324.
Description CAS Number: 1227911-45-6

Chemical Name: (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide

Molecular weight: 462.6

Formula: C25H34N8O

Solubility: DMSO (> 25 mg/ml)

Physical Properties: Off-white solid

Purity: >98% by HPLC NMR (Conforms)