Nitisinone

Overview
Catalog #	bs-82966c-50-mg
Product Name	Nitisinone
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.
Description	CAS Number: 104206-65-7 Chemical Name: 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione Molecular weight: 329.23 Formula: C14H10F3NO5 Solubility: DMSO (>10 mg/ml) Ethanol (10 mg/ml) Physical Properties: Beige solid Purity: >98% by TLC (NMR Conforms)