POB

Overview
Catalog #	bs-82917c-10-mg
Product Name	POB
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Pyridoxal 5’-phosphate – dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 µM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.
Description	CAS Number: 946135-39-3 Chemical Name: N-(4’-Pyridoxyl)-L-Ornithine(BOC)-Ome Molecular weight: 397.47 Formula: C19H31N3O6 Solubility: Ethanol (25 mg/ml) DMSO (25 mg/ml) Water (2 mg/ml) Physical Properties: White solid Purity: 98% by HPLC, NMR (Confirms)