RepSox

Overview
Catalog #	bs-82912c-5-mg
Product Name	RepSox
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	RepSox is a potent (IC50 ALK5 auto-P= 4 nM; IC50 TGF-b cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1 RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2 It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4
Description	CAS Number: 446859-33-2 Chemical Name: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine; E-616452; SNJ 2511 Molecular weight: 287.32 Formula: C17H13N5 Solubility: DMSO (>25 mg/ml) Ethanol (10 mg/ml) Physical Properties: Pale yellow solid Purity: 99% by HPLC, NMR (Conforms)