| XMU-MP-1 is a potent, reversible, and selective inhibitor of the HIPPO pathway kinases MST1 and MST2 (IC50s = 71 nM and 38 nM respectively).1 It promoted liver repair/regeneration in mice and attenuated acetaminophen-induced liver injury. In a subarachnoid hemorrhage mouse model, XMU-MP-1 alleviated neurological deficits, brain edema, neuroinflammation, and white matter injury.2 XMU-MP-1 was also cardioprotective in mice with transverse aortic constriction3 and against ischemia/reperfusion injury4. |
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