XMU-MP-1

Overview
Catalog #	bs-82842c-5-mg
Product Name	XMU-MP-1
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	XMU-MP-1 is a potent, reversible, and selective inhibitor of the HIPPO pathway kinases MST1 and MST2 (IC50s = 71 nM and 38 nM respectively).1 It promoted liver repair/regeneration in mice and attenuated acetaminophen-induced liver injury. In a subarachnoid hemorrhage mouse model, XMU-MP-1 alleviated neurological deficits, brain edema, neuroinflammation, and white matter injury.2 XMU-MP-1 was also cardioprotective in mice with transverse aortic constriction3 and against ischemia/reperfusion injury4.
Description	CAS Number: 2061980-01-4 Chemical Name: 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e]diazepin-2-yl)amino]benzenesulfonamide Molecular weight: 416.47 Formula: C17H16N6O3S2 Solubility: DMSO (15 mg/ml) Physical Properties: Yellow solid Purity: >98% by HPLC, NMR (Conforms)