iJMJD6

Overview
Catalog #	bs-82775c-5-mg
Product Name	iJMJD6
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins.1 Exhibited antiproliferative effects in HeLa (EC50 = 1.49 µM), SMCC7721 (EC50 = 9.37 µM), and MCF7 (EC50 = 9.53 µM) cells.2 Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.2
Description	CAS Number: 899548-78-8 Chemical Name: 3-(3H-Imidazo[4,5-c]pyridine-2-yl)-6-methylchromen-2-one Molecular weight: 277.28 Formula: C16H11N3O2 Solubility: DMSO (>12 mg/ml with warming) Physical Properties: Yellow solid Purity: >98% HPLC, NMR (Conforms)