ZJ43

Overview
Catalog #	bs-82721c-5-mg
Product Name	ZJ43
Specifications
Storage Buffer	Pale orange solid
Storage Condition	-20°C
Target
Product Information	ZJ43 is potent inhibitor of glutamate carboxypeptidases II (Ki = 0.8 nM) and III (Ki = 23 nM).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It potently (IC50 = 2.4 nM) inhibited the ability of glutamate carboxypeptidase II to hydrolyze the neurotransmitter N-acetylaspartylglutamate (NAAG) resulting in an increase in synaptic levels of group II mGluRs. Peripherally administered ZJ43 increased the activation of mGluR3 by NAAG released from peripheral sensory neurites resulting in analgesia.2,3 ZJ43 has also shown efficacy in other inflammatory pain models.4,5
Description	CAS Number: 723331-20-2 Chemical Name: N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid Molecular weight: 304.30 Formula: C12H20N2O7 Solubility: DMSO (>25 mg/ml) Water (>25 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)