Z-Phe-Tyr-CHO
Overview | |
Catalog # | bs-82643c-1-mg |
Product Name | Z-Phe-Tyr-CHO |
Specifications | |
Storage Buffer | Yellow solid |
Storage Condition | -20°C |
Target | |
Product Information | A potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2 |
Description | CAS Number: 167498-29-5 Chemical Name: Molecular weight: 446.50 Formula: C26H26N2O5 Solubility: DMSO (30 mg/ml) Ethanol (50 mg/ml) Physical Properties: Off-white to pale yellow solid Purity: 98% by TLC, NMR (Conforms) |