XIB4035
| Overview | |
| Catalog # | bs-82277c-5-mg |
| Product Name | XIB4035 |
| Specifications | |
| Conjugation | Unconjugated |
| Storage Buffer | Yellow solid |
| Storage Condition | RT |
| Target | |
| Background | A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson’s disease therapeutics.4 |
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