YM-155

Overview
Catalog #	bs-82268c-5-mg
Product Name	YM-155
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	A novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1 Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2 Induces DNA damage.3 Induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4
Description	CAS Number: 781661-94-7 Chemical Name: 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide Molecular weight: 443.30 Formula: C20H19BrN4O3 Solubility: DMSO (25 mg/ml) Physical Properties: Tan to yellow solid Purity: >98% by TLC NMR (Conforms)