24(S)-Hydroxycholesterol

Overview
Catalog #	bs-82183c-1-mg
Product Name	24(S)-Hydroxycholesterol
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	24(S)-Hydroxycholesterol is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in neuroblastoma cells3, possibly via a necroptosis pathway4. 24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM).5 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications.6,7 It was also able to reduce Aβ production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.7
Description	CAS Number: 474-73-7 Chemical Name: Molecular weight: 402.66 Formula: C27H46O2 Solubility: DMSO (10 mg/ml) Ethanol (10 mg/ml) Physical Properties: White solid Purity: 99% by HPLC, NMR (Conforms)