PKSI-527

Overview
Catalog #	bs-80453C
Product Name	PKSI-527
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:474 Formula:C25H31N3O4·HCl Purity:>97% Solubility:Soluble in Water (up to 5 mg/ml) Chemical Name:trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide, hydrochloride
Description	Selective inhibitor of plasma kallikrein (PLK) (Ki = 0.81 µM) that attenuates arthritis and renal damage in rats with adjuvant-induced arthritis1,2. Its combination with NO donor GSNO in blood samples led to strong platelet inhibition and thrombolysis3. Blocked PLK-dependent TGF-β activation and significantly reduced hepatic apoptosis and mortality in a mouse model of acute liver injury4.