680C91
| Overview | |
| Catalog # | bs-80259C |
| Product Name | 680C91 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:238.27 Formula:C15H11FN2 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml) Chemical Name:6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole |
| Description | A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM)1,2. Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal2. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand4. |
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