6-Thioguanine
| Overview | |
| Catalog # | bs-80162C |
| Product Name | 6-Thioguanine |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:167.19 Formula:C5H5N5S Purity:>98% Solubility:Soluble in DMF (up to 1.5 mg/ml with warming) Chemical Name:2-Amino-6-mercaptopurine |
| Description | After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity. |
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