AAL-993

Overview
Catalog #	bs-80022C
Product Name	AAL-993
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:371.36 Formula:C20H16F3N3O Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml). Chemical Name:2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide
Description	Inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-ß, cKit, and CSF-1R are also inhibited at higher concentrations (IC50’s 640 nM, 236 nM and 380 nM respectively). Screening studies have shown no inhibitory activity against a range of other kinases. X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation. Cell permeable, active in vivo and in whole animal studies.