New to Bioss? Enjoy 35% of your first order. Use code "FirstOrder35" - Offer valid for new U.S. Customers on direct orders only

(+/-)-Verapamil . hydrochloride (USP Grade)

Overview
Catalog # bs-75526c-100mg
Product Name (+/-)-Verapamil . hydrochloride (USP Grade)
Specifications
Storage Buffer Powder
Storage Condition Stable for 2 years after receipt when stored at +4°C.
Target
Product Information CAS Number: 152-11-4

Molecular formula: C27H38N2O4 . HCl

Molecular weight: 454.6 . 36.5

Purity: >99% (NMR)

Appearance: White powder.

Solubility: Soluble in methanol (50 mg/ml), ethanol or water.

InChiKey: DOQPXTMNIUCOSY-UHFFFAOYSA-N

SMILES: [Cl-].COC1=C(OC)C=C(CC[NH+](C)CCCC(C#N)(C(C)C)C2=CC(OC)=C(OC)C=C2)C=C1
Description alpha1-Adrenergic receptor (alpha-AR) antagonist. Prototypical calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Vasodilator known to reduce the renal clearance of digoxin and used to control hypertension, angina, cardiac arrhythmia and vascular headaches. Apoptosis inducer in primary and metastatic colon adenocarcinoma human cell lines in vitro. Inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein) which are often over-expressed in certain tumor cell lines. Substrate of CYP3A4 and CYP2C6. Used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Anti-diabetic in animal models by limiting TXNIP expression.