Z-VAD-FMK (Cell permeable)
| Overview | |
| Catalog # | bs-75289c-1mg |
| Product Name | Z-VAD-FMK (Cell permeable) |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 3 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 187389-52-2 and 634911-81-2 Molecular formula: C22H30FN3O7 Molecular weight: 467.5 Purity: >95% (HPLC) Appearance: White solid. Solubility: Soluble in DMSO, acetonitrile or dimethyl formamide. InChiKey: MIFGOLAMNLSLGH-SXUUOERCBK SMILES: [H][C@](NC(=O)OCC1=CC=CC=C1)(C(C)C)C(=O)N[C@@H](C)C(=O)NC(CC(=O)OC)C(=O)CF |
| Description | Cell permeable, non-selective broad-spectrum caspase inhibitor [1, 3, 7, 8]. Binds irreversibly to the catalytic site of caspase proteases [1]. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability [1]. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction [2-4, 6, 9]. Decreases proteasome activity [5]. Potent inhibitor of caspase-1 activation in NLRP3/NALP3-induced cells [10]. Used in apoptosis and inflammasome studies. |
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