| Overview |
| bs-70289r-100ul |
| Testicular Receptor 2 (TR2) Antibody |
| WB |
| Specific for endogenous levels of the ~64 kDa TR2 protein. |
| Human, Mouse, Rat |
| Specifications |
| Unconjugated |
| Rabbit |
| Fusion protein from the N-terminal region of mouse TR2. |
| Polyclonal |
| IgG |
| Lot Dependent |
| Neat whole antiserum |
| Neat whole antiserum |
| Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year. |
| Target |
| 22025 |
| Q505F1 |
| NR2C 1 antibody, NR2C1 antibody, NR2C1_HUMAN antibody, NUCLEAR HORMONE RECEPTOR TR2 antibody, Nuclear receptor subfamily 2 Group C isoform antibody, Nuclear receptor subfamily 2 group C member 1 antibody, Orphan nuclear receptor TR2 antibody, Testicular receptor 2 antibody, TR 2 antibody, TR2 antibody, TR2-11 antibody |
| Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. It is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA directly interacting with HDAC3 and HDAC4 via DNA-binding domains (Franco et al., 2003). TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands (Hun et al., 2002). In addition, TR2 has recently been shown to form a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression (Lin et al., 2008). |
| Application Dilution |
| WB |
1:300-5000 |
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