PR-619 --- Deubiquitinylating Enzyme (DUB) Inhibitor

Overview
Catalog #	bs-60199c-2-mg-solid
Product Name	PR-619 --- Deubiquitinylating Enzyme (DUB) Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 223.28 Formula: C7 H5 N5 S2 CAS Number: 2645-32-1 InChi Key: ZXOBLNBVNROVLC-UHFFFAOYSA-N InChi: InChI=1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12) Smiles: NC1N=C(N)C(=CC=1SC#N)SC#N Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	PR-619 is a cell-permeable, non-selective, reversible broad-range inhibitor of the deubiquitinylating enzymes (DUBs) with IC50 of 1-20 μM. PR-619 is shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 μM, 0.5 to 20 h) without direct impairment of proteasomal proteolysis. PR-619 treatment results in upregulation of both K48 - and K63-linked polyUb chains. It induces HCT116 cell death with EC50 ~6.3 μM.