IOX1 --- 2OG Oxygenases Inhibitor
| Overview | |
| Catalog # | bs-60195c-2mg-solid |
| Product Name | IOX1 --- 2OG Oxygenases Inhibitor |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 189.17 Formula: C10 H7 N O3 CAS Number: 5852-78-8 InChi Key: JGRPKOGHYBAVMW-UHFFFAOYSA-N InChi: InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14) Smiles: OC1C=CC(=C2C=CC=NC=12)C(O)=O Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | IOX1 is a cell-permeable broad-spectrum inhibitor of most 2OG oxygenases. It inhibits histone demethylase JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX with IC50 at 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM respectively. IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. |
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