Daidzein-2c, Osteogenic Modulator

Overview
Catalog #	bs-60158c-2mg-solid
Product Name	Daidzein-2c, Osteogenic Modulator
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 296.32 Formula: C18 H16 O4 CAS Number: 97846-18-9 InChi Key: DEQMUPGWSXUDKV-UHFFFAOYSA-N InChi: InChI=1S/C18H16O4/c1-11(2)22-14-7-8-15-17(9-14)21-10-16(18(15)20)12-3-5-13(19)6-4-12/h3-11,19H,1-2H3 Smiles: CC(C)OC1C=C2OC=C(C(=O)C2=CC=1)C1C=CC(O)=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	Daidzein-2c is a potent synthetic daidzein analog, has osteogenic induction potentials on human Mesenchymal Stem Cells (MSC). Human bone marrow derived mesenchymal stem cells from three different donors were treated with Daidzein-2c and shown to exhibit enhanced osteogenesis when compared to daidzein or estrogen treatment. The enhanced osteogenic induction by Daidzein-2c resulted in increased osterix (Sp7), alkaline phosphatase (ALP), osteopontin (OPN), and insulin-like growth factor 1 (IGF-1), which are osteogenic factors that regulate the maturation of osteogenic progenitor cells into more differentiated osteoblast cells. It serves as a useful chemical tool to further validate and develop novel treatments of osteoporosis via promoting bone formation.