ML141 --- Cdc42 GTPase Inhibitor

Overview
Catalog #	bs-60134c-2mg-solid
Product Name	ML141 --- Cdc42 GTPase Inhibitor
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 407.49 Formula: C22 H21 N3 O3 S CAS Number: 71203-35-5 InChi Key: QBNZBMVRFYREHK-UHFFFAOYSA-N InChi: InChI=1S/C22H21N3O3S/c1-28-19-11-7-17(8-12-19)22-15-21(16-5-3-2-4-6-16)24-25(22)18-9-13-20(14-10-18)29(23,26)27/h2-14,22H,15H2,1H3,(H2,23,26,27) Smiles: COC1C=CC(=CC=1)C1CC(=NN1C1C=CC(=CC=1)S(N)(=O)=O)C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO up to 100 mM Appearance: Solid Power. Shelf Life: 1.0 years
Description	ML141 is a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase. The EC50 for Cdc42 wild type and Cdc42Q61L mutant were 2.1 and 2.6 μM respectively. It has excellent selectivity for Cdc42 with no inhibition toward Rho and Rac in the same GTPase family, including Rac1, Rab2 and Rab7. In cellular assays ML141 inhibited Cdc42-related filopodia formation and cell migration.