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APEX1 Polyclonal Antibody

Applications

  • WB
  • IF(ICC)
  • IP
  • IF

Reactivity

  • Human
Overview
Catalog # bs-55012R
Product Name APEX1 Polyclonal Antibody
Applications WB, IF(ICC), IP, IF
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human APEX1 (NP_542380.1).
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 328
Swiss Prot P27695
Subcellular location Cytoplasm, Nucleus
Synonyms APEX1;APE;APE1;APEN;APEX;APX;HAP1;REF1
Background Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Application Dilution
WB 1:300-5000
IF(ICC) 1:50-200
IP 1-2ug
IF