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RbAp 46/48 Monoclonal Antibody

Applications

  • WB

Reactivity

  • Human
Overview
Catalog # bs-51000R
Product Name RbAp 46/48 Monoclonal Antibody
Applications WB
Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Source Monoclonal antibody raised in mouse against the full length human RbAp48 protein (Retinoblastoma-binding protein p48) fused to GST. The antibody recognizes both RbAp48 and RbAp46
Clonality Monoclonal
Clone # 6D1
Isotype IgG2b
Concentration Not Determined
Purification Ascites fluid from mouse containing 0.05% azide
Storage Buffer Ascites fluid with 0.05% sodium azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 5928
Swiss Prot Q09028
Synonyms Histone-binding protein RBBP4, RBBP4, p48, RBBP-4, RBAP48
Background Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Application Dilution
WB 1:300-5000