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MAP 1A/1B LC3 A/B Polyclonal Antibody, PE-Cy7 Conjugated

Applications

  • FCM

Reactivity

  • Human
  • Rat

Predicted Reactivity

  • Mouse
  • Dog
  • Cow
  • Pig
  • Horse
  • Chicken
Overview
Catalog # bs-4309R-PE-Cy7
Product Name MAP 1A/1B LC3 A/B Polyclonal Antibody, PE-Cy7 Conjugated
Applications FCM
Reactivity Human, Rat
Predicted Reactivity Mouse, Dog, Cow, Pig, Horse, Chicken
Specifications
Conjugation PE-Cy7
Host Rabbit
Source KLH conjugated synthetic peptide derived from human MAP LC3 Alpha
Immunogen Range 25-121/121
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 54901, 84557
Swiss Prot Q9H492, Q9GZQ8
Subcellular location Cytoplasm, Cell membrane
Synonyms Microtubule-associated proteins 1A/B light chain 3A; Microtubule-associated proteins 1A/B light chain 3B; Microtubule-associated proteins 1Beta light chain 3A; Microtubule-associated proteins 1Beta light chain 3A; MAP1B LC3 A; MAP LC3 Beta; MAP-LC3 Beta; MAP1 light chain 3-like protein 1.MAP1LC3B.MLP3A_HUMAN
Background Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3 Beta) and MAP-light chain 3 alpha (MAP-LC3 alpha) are subunits of both MAP1A and MAP1B. MAP-LC3M Beta, a homolog of Apg8p, is essential for autophagy and associated to the autophagosome membranes after processing. Two forms of LC3 Beta, the cytosolic LC3-I and the membrane-bound LC3-II, are produced post-translationally. LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3, followed by the conversion of a fraction of LC3-I into LC3-II. LC3 enhances fibronectin mRNA translation in ductus arteriosus cells through association with 60S ribosomes and binding to an AU-rich element in the 3? untranslated region of fibronectin mRNA. This facilitates sorting of fibronectin mRNA onto rough endoplasmic reticulum and translation. MAP LC3 Beta may also be involved in formation of autophagosomal vacuoles. It is expressed primarily in heart, testis, brain and skeletal muscle.
Application Dilution
FCM 1:20-100