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STAT3 (Ser727) Polyclonal Antibody, PE-Cy5 Conjugated

Applications

  • WB
  • FCM

Reactivity

  • Human
  • Rat
  • Rabbit

Predicted Reactivity

  • Mouse
  • Dog
  • Cow
  • Sheep
  • Pig
  • Chicken
  • Guinea Pig
Overview
Catalog # bs-3429R-PE-Cy5
Product Name STAT3 (Ser727) Polyclonal Antibody, PE-Cy5 Conjugated
Applications WB, FCM
Reactivity Human, Rat, Rabbit
Predicted Reactivity Mouse, Dog, Cow, Sheep, Pig, Chicken, Guinea Pig
Specifications
Conjugation PE-Cy5
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human STAT3 around the phosphorylation site of Ser727
Modification Site Ser727
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 6774
Swiss Prot P40763
Subcellular location Cytoplasm, Nucleus
Synonyms APRF; HIES; ADMIO; Signal transducer and activator of transcription 3; Acute-phase response factor; STAT3
Background Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
Application Dilution
WB 1:300-5000
FCM 1:20-100